Anadrol is known (sometimes notoriously) as being one of the contenders for being the strongest oral anabolic steroid commercially available. It closely competes with Dianabol (Methandrostenolone), and steroid-using bodybuilding circles have always debated which of the two are stronger. Anadrol is the brand and trade name for the anabolic steroid more formally known as Oxymetholone. This is not to be confused with Oxandrolone, which is otherwise known as Anavar. Oxymetholone is Anadrol. Anadrol’s details were first released in 1959. Almost immediately after, the pharmaceutical company Syntex sold Oxymetholone under the name Anadrol-50 while Parke Davis & Co. also manufactured it, though they did so under the Androyd trade name. After its initial release onto prescription markets, Anadrol was quickly prescribed and used for a multitude of medical conditions ranging from geriatric atrophy to combating infections. It’s most noted and popular use as a medication, however, was in the treatment of anemia. Anadrol was prescribed here to increase the red blood cell count and hemoglobin levels of the anemic individual.
This was because of Anadrol’s ability to stimulate erythropoiesis at a very high rate. Although all anabolic steroids exhibit this capability, Anadrol’s ability to stimulate erythropoiesis far exceeds that of any other anabolic steroid. In these cases, Anadrol has been shown in studies to increase red blood cell production by a factor of 5 fold. As far as its general effectiveness as an anabolic steroid for muscle-building purposes is concerned, studies have demonstrated that it has exerted notable anabolic effects on muscle-wasting AIDS patients, causing them to actually gain 8kg of weight while those who were administered a placebo not only lost weight but also experienced an increase in mortality. It is for this reason that Anadrol tends to be prescribed almost primarily in this day and age for AIDS patients and muscle wasting diseases.
Chemical Characteristics of Anadrol
Anadrol is derived from Dihydrotestosterone (DHT), belonging to the family of Dihydrotestosterone (DHT) derived anabolic steroids. This means that Anadrol is basically Dihydrotestosterone modified. Other compounds belonging to this ‘DHT family’ of anabolic steroids include Winstrol, Primobolan, Masteron, Anavar, as well as several others which are all derivatives of the parent anabolic steroid DHT. The common factor in all of these DHT-derivative analogues is that, in one way or another, they are all modified forms of DHT and thus DHT could be considered the ‘parent’ or ‘progenitor’ hormone of these anabolic steroids. Anadrol differs from its parent hormone DHT by the addition of a methyl group attached to it, as well as a 2-hydroxymethylene group attached to a carbon in the first cycloalkane ring of the steroid structure. These modifications allow Anadrol to remain active in muscle tissue, which is where Dihydrotestosterone would normally be rendered inactive by its reduction to other metabolites once it enters muscle tissue. The enzyme responsible for doing this to Dihydrotestosterone, which is present in large amounts in muscle tissue, is 3-hydroxysteroid dehydrogenase. With the chemical modifications mentioned, this enzyme does not interact with Anadrol. This allows Anadrol to be heavily active in muscle tissue, and lends to its very strong potency. Anadrol possesses an anabolic rating of 320 (a little more than 3 times the strength of Testosterone, with its anabolic rating of 100). It has also been determined that Anadrol also possesses reduced androgenic strength compared to that of Testosterone, where Anadrol holds an androgenic rating of 45 (compared to Testosterone’s androgenic rating of 100).
One of the unique and mysterious characteristics possessed by Anadrol is that although it is a derivative of DHT, it possesses a very high level of Estrogenic activity. It is typically known that DHT-derivative anabolic steroids should be unable to convert into Estrogen via the aromatase enzyme and therefore elicit no Estrogenic effects, but this is very different with Anadrol. Anadrol is well known for causing water retention, bloating, gynecomastia, and other Estrogenic effects on the body even though it does not convert into Estrogen. It is believed that Anadrol itself acts as an estrogen in certain tissues. This will be further expanded upon and discussed later on, but it is imperative for any potential user to understand that first and foremost that although Anadrol is a DHT-derivative, one will not experience the lean hard gains typically seen with DHT-derivatives. Anadrol is notorious for its Estrogenic effects that cannot be combated with aromatase inhibitors due to its inability to convert into Estrogen.
Anadrol is an orally active anabolic steroid, which means it has been C17 Alpha Alkylated in order to allow the anabolic steroid to make the first pass through the liver without suffering destruction through liver metabolism. Anadrol, however, is very well known for its very harsh hepatotoxicity, which will be explained in greater detail shortly. Anadrol’s chemical modifications and chemical structure (including its C17 Alpha Alkylation) makes it very resistant to hepatic breakdown (liver metabolism). The greater resistance a substance has to hepatic breakdown, the more toxicity and strain on the liver will be experienced – and Anadrol is notorious for its liver toxicity, and is perhaps regarded as the most liver toxic oral anabolic steroid conventionally available.
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